1. Adrian Peterson vs. GB – Last year he went off against the Packers. He’ll top 125 yards with 1-2 TDs in this one.
2. LeSean McCoy vs. NYG – He’s been a nightmare for the Giants historically.
3. Marshawn Lynch vs. Stl.- Beast mode will top 100 yards with multiple scores in this one.
4. Jamaal Charles vs. Cle – The Chiefs are getting the most out of Charles this year. Expect another stellar afternoon in this one.
Not far behind
Frank Gore vs. Jax – He would rate higher but it’s likely that the 49ers will have their back-ups in by the 3rd quarter.
Reggie Bush vs. Dal – Expect the Lions to isolate Bush on passes out of the backfield this week.
Knowshon Moreno vs. Was – The passing game will open up holes all afternoon for Moreno.
Rounding things out
Eddie Lacy vs. Min – The injuries at receiver have forced GB to rely more heavily on the running game.
Stevan Ridley vs. Mia – TE Gronkowski’s return will open up things for the Ridley and the running game.
Alfred Morris vs. Den – The Redskins will try and play keep away from Manning.
Le’veon Bell vs. Oak – The Steelers commitment to the run has been a boon to this offense.
Darren Sproles vs. Buf – If TE Jimmy Graham is out, Sproles importance in the passing game increases exponentially.
Fred Jackson vs. NO – He has supplanted CJ Spiller as the top RB with the latter being less than 100%.
Giovani Bernard vs. NYJ – His ability to catch passes out of the backfield will serve him well vs. a Jets team that defends the run well.
Chris Ivory vs. Cin – He’s a flex play vs. the Bengals this week.
Darren McFadden vs. Pit – Coming off the bye, his leg should be completely healed.
Rashad Mendenhall vs. Atl – The Falcons D can be run on.
Lamar Miller vs. NE – The Patriots surrendered a lot of yards on the ground vs. the Jets. Miller is a flex play until he proves otherwise.
Potential Bust – Beware
CJ Spiller vs. NO – Spiller’s been a huge fantasy disappointment and will find it tough to run in NO.